Hydrogen Peroxide → HCID 59278114, compound

Participants

Reaction Conditions

Reaction Steps

To a rapidly stirred solution of 2-Methyl-propane-2-sulfinic acid [(S)-1-(2-cyano-pyridin-4-yl)-propyl]-amide (4.40 g, 16.6 mmol) in DMSO (70 mL) at 10° C. was added potassium carbonate (3.00 g, 21.7 mmol) portionwise and hydrogen peroxide (30 wt. % in water, 6.16 mL, 54.4 mmol) dropwise. The reaction was stirred at room temp. for 3.5 h. The reaction was cooled to 5° C., diluted with ethyl acetate (100 mL) and quenched with sodium thiosulfate solution (10% in water, 25 mL), stirred at 5° C. for 1 h. The organic phase was separated, the aqueous phase was extracted with ethyl acetate (4×100 mL), the combined organic extracts were washed with water (3×50 mL), brine, dried over sodium sulfate, filtered and concentrated to give 4-[(S)-1-(2-Methyl-propane-2-sulfinylamino)-propyl]-pyridine-2-carboxylic acid amide (5.50 g, 99%) as a thick oil.

Provenance & Evidence