Hydrochloric Acid → HCID 59278515, compound

Participants

Reaction Steps

To a solution of 4-[(S)-1-(2-Methyl-propane-2-sulfinylamino)-propyl]-pyridine-2-carboxylic acid amide (5.50 g) in methanol (50 mL) was added hydrochloric acid (4 N in dioxane, 4.3 mL, 17.3 mmol) and the mixture was stirred for 2 h. Additional hydrochloric acid (4 N in dioxane, 0.5 mL, 2.0 mmol) was added. The mixture was stirred for another 1.5 h. The mixture was concentrated to remove methanol and then diluted with ethyl acetate (400 mL), washed with sat. sodium bicarbonate solution, The aqueous layer was extracted with ethyl acetate (4×100 mL). the combined organic extracts were washed with brine, dried over sodium sulfate, filtered and concentrated to give 4-((S)-1-Amino-propyl)-pyridine-2-carboxylic acid amide (3.50 g, 100%)

Provenance & Evidence