Hydrochloric Acid → (S)-1-(2-methanesulfonyl-thiazol-5-yl)-propylamine hydrochloride

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Reaction Steps

A solution of 2-methyl-propane-2-sulfinic acid [(S)-1-(2-methanesulfonyl-thiazol-5-yl)-propyl]-amide (80 mg, 0.25 mmol) in methanol (5 mL) was treated with hydrochloric acid (4 N in dioxane, 1 mL, 4 mmol). The mixture was stirred at room temp. for 1 h and then concentrated. The residue was taken up in dichloromethane (2 mL) and diluted with hexanes (10 mL). Concentration gave (S)-1-(2-Methanesulfonyl-thiazol-5-yl)-propylamine hydrochloride (62 mg, 98%) as a yellow hygroscopic solid, that was used without further purification.

Provenance & Evidence