Water → HCID 87536609, compound

Participants

Reaction Steps

To a solution of tert-butyl 4-(propylthiomethyl)thiazol-2-ylcarbamate (16 mmol) in MeOH (175 mL) was added a solution of oxone (3.0 eq, 29.5 g) in H2O (75 mL) and stirred for 3 hours at room temperature. H2O was added to the reaction mixture and extracted twice with EtOAc. The combined organic layers were dried over Na2SO4 and concentration afforded the title sulfone (4.71 g, 97% yield) as a yellow/orange solid.

Provenance & Evidence