HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2068006Generated: October 31, 2026
4-(Toluene-4-sulfonylmethyl)-thiazol-2-ylamine → HCID 25141449, compound
https://huagongshe.com/reaction/2068006
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-(Toluene-4-sulfonylmethyl)-thiazol-2-ylamine | HCID 653276 | — |
| Reactant | 1,2-Dichloro-4-(isocyanatomethyl)benzene | HCID 2733368 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 25141449 | HCID 25141449 | 66% |
Reaction Steps
4-(Toluene-4-sulfonylmethyl)-thiazol-2-ylamine (0.5 mmol) was dissolved in THF (3 ml) and 3,4-dichlorobenzylisocyanate (1.2 eq., 0.6 mmol) was added. The reaction was heated by microwave for 30 min. at 150° C. Solvent was removed in vacuo. The crude product was purified by column chromatography eluting with a gradient of 0-20% EtOAc (with 10% MeOH) in hexanes to give the title compound as a white solid in 66% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08293919B2 |
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| Source dataset | uspto-grants-2012_10 |
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| ORD ID | ord-fde822abe8504bde837993ac0d4cc2a1 |
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| Source note | uspto-grants-2012_10 |
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