Phenyl chloroformate → HCID 87536672, compound

Participants

Reaction Steps

To a cooled (0° C.) solution of 4-(propylsulfonylmethyl)thiazol-2-amine HCl-salt (3.99 g, 15.5 mmol) and DMAP (5 mol %, 95 mg) in pyridine (30 mL) was added a solution of phenyl chloroformate (1 eq, 1.96 mL) in THF (30 mL) drop wise. The reaction mixture was stirred at room temperature overnight and poured onto ice/water. The mixture was allowed to warm to room temperature and the solids were filtered off. The solids were washed with water, 10% aq. sodium bicarbonate, and dried in vacuo affording the title phenyl carbamate (1.22 g, 51% yield) as a solid.

Provenance & Evidence