Water → Tert-butyl 4-(methylsulfonyl)piperazine-1-carboxylate

Participants

Reaction Steps

Methanesulphonyl chloride (2.28 ml) was added dropwise to a solution of 1-(tert-butoxycarbonyl)piperazine (5 g) in methylene chloride (90 ml) containing triethylamine (4.5 μl). The solution was stirred at ambient temperature for 24 hours. The solution was poured onto cooled water and extracted with methylene chloride. The organic phase was separated, washed with brine and dried over magnesium sulphate and evaporated to give tert-butyl 4-(methylsulphonyl)piperazine-1-carboxylate (7 g).

Provenance & Evidence