HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-(Benzyloxy)-4-chloro-6-methoxyquinazoline hydrochloride → 7-(Benzyloxy)-4-chloro-6-methoxyquinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-(Benzyloxy)-4-chloro-6-methoxyquinazoline hydrochloride | HCID 22030836 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 7-(Benzyloxy)-4-chloro-6-methoxyquinazoline | HCID 10661998 | 97.1% |
Reaction Steps
7-Benzyloxy-4-chloro-6-methoxyquinazoline hydrochloride (3.35 g) was dissolved in methylene chloride (250 ml) and washed with aqueous sodium hydrogen carbonate until the pH of the aqueous solution was adjusted to pH8. The organic layer was washed with brine, dried (MgSO4) and evaporated to give 7-benzyloxy-4-chloro-6-methoxyquinazoline free base (2.9 g, 96%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293902B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-4ff5879bb3af4c149e560746c2b82a46 |
| Source note | uspto-grants-2012_10 |