反应详情

3-(3-Benzyloxypropyl)imidazolidine-2,4-dione (1.3 g, 5.26 mmol) was dissolved in methanol (15 ml) and the system purged with nitrogen. 10% Palladium on carbon (130 mg, 10% by mass) and a few drops of glacial acetic acid were added and the mixture stirred under a hydrogen atmosphere (1 atmosphere) for 3 days. The mixture was filtered and concentrated under reduced pressure. The residue was purified by column chromatography eluting with methylene chloride/methanol (98/2 to 95/5) to give 3-(3-hydroxypropyl)imidazolidine-2,4-dione (606 mg, 73%) as a viscous oil which crystallised on standing.

1. customthe system purged with nitrogen
2. addition10% Palladium on carbon (130 mg, 10% by mass) and a few drops of glacial acetic acid were added
3. filtrationThe mixture was filtered
4. concentrationconcentrated under reduced pressure
5. customThe residue was purified by column chromatography
6. washeluting with methylene chloride/methanol (98/2 to 95/5)