Tert-butyl octahydropyrrolo(3,4-c)pyrrole-2-carboxylate → tert-butyl 5-(3-(3-(trifluoromethoxy)phenylsulfonyl)quinolin-8-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

HRID 2068138Notes

Reaction equation

HRID 2068138 reaction equation
[CH2:1]1[CH:5]2[CH2:6][NH:7][CH2:8][CH:4]2[CH2:3][N:2]1[C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10].I[C:17]1[CH:18]=[CH:19][CH:20]=[C:21]2[C:26]=1[N:25]=[CH:24][C:23]([S:27]([C:30]1[CH:35]=[CH:34][CH:33]=[C:32]([O:36][C:37]([F:40])([F:39])[F:38])[CH:31]=1)(=[O:29])=[O:28])=[CH:22]2>>[F:40][C:37]([F:38])([F:39])[O:36][C:32]1[CH:31]=[C:30]([S:27]([C:23]2[CH:24]=[N:25][C:26]3[C:21]([CH:22]=2)=[CH:20][CH:19]=[CH:18][C:17]=3[N:7]2[CH2:6][CH:5]3[CH2:1][N:2]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:3][CH:4]3[CH2:8]2)(=[O:28])=[O:29])[CH:35]=[CH:34][CH:33]=1

Participants

3

Reactant 2

HCID 4142526Tert-butyl octahydropyrrolo(3,4-c)pyrrole-2-carboxylateHCID 687290868-Iodo-3-(3-(trifluoromethoxy)phenylsulfonyl)quinoline

Product 1

HCID 25196508tert-butyl 5-(3-(3-(trifluoromethoxy)phenylsulfonyl)quinolin-8-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylateYield 79%

Procedure

The title compound was prepared by analogy to the procedure of Example 1.3, except using tert-butyl hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate and 8-iodo-3-(3-(trifluoromethoxy)phenylsulfonyl)quinoline. 140 mg (79%) of the title compound were obtained as a pale yellow solid.

Workup

  1. customThe title compound was prepared by analogy to the procedure of Example 1.3

Sources & evidence

ORD record
ord-60256641c81f43d7a087410e077d0805
Source dataset
uspto-grants-2012_10
Patent number
US08293913B2

Reaction notes

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