HRID2068141

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID44474550

tert-Butyl hexahydropyrrolo[3,4-b]pyrrole-1(2H)-carboxylate

C11H20N2O2

结构：O=S(=O)(c1cccc(C(F)(F)F)c1)c1cnc2c(I)cccc2c1

HCID67313511

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)N1CCC2CN(c3cccc4cc(S(=O)(=O)c5cccc(C(F)(F)F)c5)cnc34)CC21

HCID68728985

未命名化合物

收率 56%

PROCEDURE

实验过程

The title compound was prepared by analogy to the procedure of Example 1.3, except using tert-butyl hexahydropyrrolo[3,4-b]pyrrole-1(2H)-carboxylate and 8-iodo-3-(3-(trifluoromethyl)phenylsulfonyl)quinoline. 133 mg (56%) of the title compound were obtained as a pale yellow solid.

WORKUP

后处理

customThe title compound was prepared by analogy to the procedure of Example 1.3

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9cbd1c66174c4622911ea618828a0fba
来源数据集: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08293913B2
来源说明: uspto-grants-2012_10

反应 SMILES

[N:1]1([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:5][CH2:4][CH:3]2[CH2:6][NH:7][CH2:8][CH:2]12.I[C:17]1[CH:18]=[CH:19][CH:20]=[C:21]2[C:26]=1[N:25]=[CH:24][C:23]([S:27]([C:30]1[CH:35]=[CH:34][CH:33]=[C:32]([C:36]([F:39])([F:38])[F:37])[CH:31]=1)(=[O:29])=[O:28])=[CH:22]2>>[F:39][C:36]([F:37])([F:38])[C:32]1[CH:31]=[C:30]([S:27]([C:23]2[CH:24]=[N:25][C:26]3[C:21]([CH:22]=2)=[CH:20][CH:19]=[CH:18][C:17]=3[N:7]2[CH2:6][CH:3]3[CH:2]([N:1]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:5][CH2:4]3)[CH2:8]2)(=[O:29])=[O:28])[CH:35]=[CH:34][CH:33]=1