Cis-2-boc-hexahydropyrrolo[3,4-C]pyrrole → HCID 68773167, compound

HRID 2068142Notes

Reaction equation

HRID 2068142 reaction equation
[CH2:1]1[C@@H:5]2[CH2:6][NH:7][CH2:8][C@@H:4]2[CH2:3][N:2]1[C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10].I[C:17]1[CH:18]=[CH:19][CH:20]=[C:21]2[C:26]=1[N:25]=[CH:24][C:23]([S:27]([C:30]1[CH:35]=[CH:34][CH:33]=[C:32]([C:36]([F:39])([F:38])[F:37])[CH:31]=1)(=[O:29])=[O:28])=[CH:22]2>>[F:39][C:36]([F:37])([F:38])[C:32]1[CH:31]=[C:30]([S:27]([C:23]2[CH:24]=[N:25][C:26]3[C:21]([CH:22]=2)=[CH:20][CH:19]=[CH:18][C:17]=3[N:7]2[CH2:6][C@@H:5]3[CH2:1][N:2]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:3][C@@H:4]3[CH2:8]2)(=[O:29])=[O:28])[CH:35]=[CH:34][CH:33]=1

Participants

3

Reactant 2

HCID 1514452Cis-2-boc-hexahydropyrrolo[3,4-C]pyrroleHCID 673135118-Iodo-3-(3-(trifluoromethyl)phenylsulfonyl)quinoline

Product 1

HCID 68773167HCID 68773167, compoundYield 60%

Procedure

The title compound was prepared by analogy to the procedure of Example 1.3, except using (3aR,6aS)-tert-butyl hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate and 8-iodo-3-(3-(trifluoromethyl)phenylsulfonyl)quinoline. 107 mg (60%) of the title compound were obtained as a pale yellow solid.

Workup

  1. customThe title compound was prepared by analogy to the procedure of Example 1.3

Sources & evidence

ORD record
ord-f5b871d1d33e4691830a4cb243c144e4
Source dataset
uspto-grants-2012_10
Patent number
US08293913B2

Reaction notes

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