反应详情

Under a nitrogen atmosphere, (R)-4-amino-3-(4-chlorophenyl)butanoic acid hydrochloride (4.0 g, 16.0 mmol) was dissolved in water (12 ml). Into this, 1 mol/L sodium hydroxide aqueous solution was dropped, to adjust pH to 6.5. The crystallized crystal was filtrated and dried under reduced pressure to obtain a title compound (3.13 g, 14.6 mmol) (yield: 91%). The optical purity of the resultant title compound was measured by HPLC to find a value of 99.9% ee or more (conditions are shown below).

1. filtrationThe crystallized crystal was filtrated
2. customdried under reduced pressure