Hydrochloric Acid → 2-(2,6-Dimethylphenyl)-1-oxooctahydrocyclopenta[c]pyrrole-3a-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

Methyl 2-(2,6-dimethylphenyl)-1-oxooctahydrocyclopenta[c]pyrrole-3a-carboxylate (400 mg, 1.4 mmol) suspended in 5 mL of 1 M LiOH in 90% methanol was heated at 70° C. After cooling to room temperature, the reaction mixture was diluted with water, the pH adjusted to ˜1 with concentrated HCl and the product was extracted twice with ethyl acetate (15 mL). The combined organic layer was dried over anhydrous Na2SO4 and the solvent was evaporated to yield 2-(2,6-dimethylphenyl)-1-oxooctahydrocyclopenta[c]pyrrole-3a-carboxylic acid (315 mg, 82% yield). LC-MS Rt (retention time): 1.44 min, MS: (ES) m/z 274 (M+H+).

Provenance & Evidence