Potassium Phosphate, Tribasic → HCID 87248987, compound

Participants

Reaction Steps

In a stream of nitrogen, 5.0 g (11.5 mmol) of 3,6-di-tert-butyl-2,7-dibromofluorene, 135 mg (0.60 mmol) of palladium(II) acetate, 603 mg (1.72 mmol) of (2-biphenyl)dicyclohexylphosphine, 14.5 g (68.3 mmol) of potassium phosphate, 4.7 g (34.6 mmol) of o-tolylboronic acid and 100 ml of THF were placed in a reaction container, and with stirring them at room temperature, 25 ml of water was slowly dropwise added. After the dropwise addition, the reaction solution was heated up to 50° C., and with stirring, the solution was heated for 10 hours. Thereafter, the reaction solution was quenched with 1N hydrochloric acid, and a soluble matter was extracted with ether. The organic phase was washed with water, a sodium hydrogencarbonate aqueous solution and a saturated saline solution. Thereafter, the thus washed organic phase was dried using magnesium sulfate, and the solvent was distilled off to obtain an unpurified desired product. The conversion ratio as measured by HPLC was 86%.

Provenance & Evidence