Iodine → HCID 178419333, compound

Participants

Reaction Steps

Into a round-bottom flask was dissolved 5-bromo-1H-indazole (1.99 g, 0.0101 mol) in N,N-dimethylformamide (10.0 mL). To this stirred solution was added potassium hydroxide (2.03 g, 0.0362 mol) then a cold solution of iodine (2.82 g, 0.0111 mol) in N,N-dimethylformamide (12.0 mL, 0.155 mol) was added dropwise. The mixture was stirred at room temperature for 2 hours before being added dropwise to an ammonium hydroxide (150 mL, 3.8 mol) solution in water (2.0 L) to give a precipate. The precipitate was collected and dried under vacuum for 18 hours to yield 3.00 g (92%) of 5-bromo-3-iodo-1H-indazole.

Provenance & Evidence