N-(1-(4-(tert-butyldimethylsilyloxy)cyclohexyl)-5-((4-(2-(pyridin-4-yl)ethyl)piperazin-1-yl)methyl)-1H-benzo[d]imidazol-2-yl)-5-(4-methoxypyridin-3-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-amine → HCID 24798636, compound

Participants

Reaction Steps

In a 20 mL vial was added N-(1-(4-(tert-butyldimethylsilyloxy)cyclohexyl)-5-((4-(2-(pyridin-4-yl)ethyl)piperazin-1-yl)methyl)-1H-benzo[d]imidazol-2-yl)-5-(4-methoxypyridin-3-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-amine (31 mg, 0.000034 mol) ethanol (1.20 mL) and 0.01M hydrogen chloride (300 uL). The reaction mixture was brought to reflux and maintained at reflux for 1 hour. The reaction mixture was concentrated to a brownish residue and purified by HPLC yielding 8.3 mg of the title compound as the bis TFA salt as a white solid.

Provenance & Evidence