Cyclopentylamine → HCID 67252904, compound

Participants

Reaction Steps

N,N-Diisopropylethylamine (19.6 uL, 0.000112 mol) was added to a solution of 2-(5-bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-ylamino)-1-(4-(tert-butyldimethylsilyloxy)cyclohexyl)-1H-benzo[d]imidazole-5-carboxylic acid (26.8 mg, 0.0000375 mol), 2-chloro-1-methylpyridinium iodide (19.2 mg, 0.0000750 mol) and 1-hydroxybenzotriazole (10.1 mg, 0.0000750 mol) tetrahydrofuran (0.40 mL). The mixture was stirred at room temperature for 20 minutes. Cyclopentanamine (0.000112 mol) was then added and the mixture stirred for 2 hours. The mixture was diluted with ethyl acetate, washed with water, dried over magnesium sulfate and purified by flash chromatography.

Provenance & Evidence