反应详情

To (4-cyclohexylamino-3-nitro-phenyl)methanol (1.46 g, 0.0058 mol) in ethanol (35 mL, 0.6 mol) was added 5% Pd/C (0.20 g, 0.00009 mol). The mixture was flushed with hydrogen then stirred for 2 hr at room temperature under 1 atm of hydrogen. The reaction mixture was concentrated and the residue purified by flash chromatography with a gradient from 40 to 100 percent ethyl acetate in hexanes to provide 1.010 g the title compound.

1. customThe mixture was flushed with hydrogen
2. concentrationThe reaction mixture was concentrated
3. customthe residue purified by flash chromatography with a gradient from 40 to 100 percent ethyl acetate in hexanes