HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → 3-Bromo-2-methyl-5-(4-hydroxythienyl)thiophene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | (4-Bromo-5-methylthiophen-2-yl)boronic acid | HCID 12184011 | — |
| Reactant | 5-Bromothiophene-2-ol | HCID 21108627 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-Bromo-2-methyl-5-(4-hydroxythienyl)thiophene | HCID 67309403 | — |
Reaction Steps
Compound 3 is mixed with 5-bromothiophen-2-ol in the presence of tetrakis(triphenylphosphine)palladium(0) [Pd(PPh3)-4] and Na2CO3 in tetrahydrofuran (THF) for 24 h at 80° C. The crude product is distillated in vacuo and purified by silica-gel column chromatography (eluent: hexane). Compound 5 (5.01 g) is obtained as a yellowish solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08298453B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-b43a2caefdbf4968b620c2b47b276cd5 |
| Source note | uspto-grants-2012_10 |