反应详情

温度

135 °C

0.378 g (3.330 mmol) of 3-hydrazinopyrazine in 12.5 ml of ethanol was added to 0.600 g (2.561 mmol) of methyl 4-oxo-3-(phenylcarbonyl)pentanoate, and the mixture was heated at 135° C. in a sealed vessel in a microwave oven for 1.5 h. The solvent was removed under reduced pressure, and the residue was taken up in dichloromethane and washed twice with in each case 25 ml of water. The combined organic phases were dried over sodium sulfate and the solvent was removed under reduced pressure. Chromatography of the residue gave 0.115 g (13.8% of theory) of a light-yellow wax.

1. customThe solvent was removed under reduced pressure
2. washwashed twice with in each case 25 ml of water
3. dry with materialThe combined organic phases were dried over sodium sulfate
4. customthe solvent was removed under reduced pressure
5. customChromatography of the residue gave 0.115 g (13.8% of theory) of a light-yellow wax