Tert-butoxycarbonylalanine → HCID 66916447, compound

HRID 2068494Notes

Reaction equation

HRID 2068494 reaction equation
C(OC([NH:8][C@H:9]([C:11](O)=O)[CH3:10])=O)(C)(C)C.[CH3:14][O:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[C@@H:22]([NH2:24])[CH3:23]>>[CH3:14][O:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[C@@H:22]([NH:24][CH2:10][C@@H:9]([NH2:8])[CH3:11])[CH3:23]

Participants

3

Reactant 2

HCID 85082Tert-butoxycarbonylalanineHCID 853082(S)-1-(2-Methoxyphenyl)ethanamine

Product 1

HCID 66916447HCID 66916447, compoundYield 12.2%

Procedure

By using N-t-butoxycarbonyl-(L)-alanine (431 mg), and (1S)-1-(2-methoxyphenyl)ethanamine (200 mg) obtained by the method described in the publication (Japanese Patent Unexamined Publication No. 54/154724) as starting materials, the title compound (33.6 mg) was obtained in the same manners as those of Reference Example 10, (1), (2), and Reference Example 3, (2).

Workup

  1. customobtained by the method

Sources & evidence

ORD record
ord-d3082bdb9e3c4aab92064ec6d6878778
Source dataset
uspto-grants-2012_10
Patent number
US08299035B2

Reaction notes

Loading…