(S)-1-(2-Methoxyphenyl)ethanamine → HCID 178489475, compound

HRID 2068495Notes

Reaction equation

HRID 2068495 reaction equation
C(OC([NH:8][C@@H:9]([C:16](O)=O)[CH2:10][C:11]1[N:15]=[CH:14][NH:13][CH:12]=1)=O)(C)(C)C.[CH3:19][O:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[C@@H:27]([NH2:29])[CH3:28]>>[NH:13]1[CH:12]=[C:11]([CH2:10][C@@H:9]([NH2:8])[CH2:16][NH:29][C@H:27]([C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=2[O:20][CH3:19])[CH3:28])[N:15]=[CH:14]1

Participants

3

Reactant 2

HCID 853082(S)-1-(2-Methoxyphenyl)ethanamineHCID 178454170HCID 178454170, compound

Product 1

HCID 178489475HCID 178489475, compoundYield 24.2%

Procedure

By using N-t-butoxycarbonyl-(D)-histidine (405 mg), and (1S)-1-(2-methoxyphenyl)ethanamine compound (200 mg) obtained by the method described in the publication (Japanese Patent Unexamined Publication No. 54/154724) as starting materials, the title compound (88 mg) was obtained in the same manner as that of Reference Example 71.

Workup

  1. customobtained by the method

Sources & evidence

ORD record
ord-54f1714595d247f19f4a49f5343c10c4
Source dataset
uspto-grants-2012_10
Patent number
US08299035B2

Reaction notes

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