Sodium Hydroxide → HCID 178423620, compound

HRID 2068522Notes

Reaction equation

HRID 2068522 reaction equation
O.[F:2][C:3]([F:46])([F:45])[C:4]1[CH:5]=[C:6]([CH2:14][N:15]([C:39]2[N:40]=[N:41][N:42]([CH3:44])[N:43]=2)[C@@H:16]2[C:22]3[CH:23]=[C:24]([CH3:28])[CH:25]=[C:26]([CH3:27])[C:21]=3[N:20]([CH2:29][C@H:30]3[CH2:35][CH2:34][C@H:33]([C:36]([OH:38])=[O:37])[CH2:32][CH2:31]3)[CH2:19][CH2:18][CH2:17]2)[CH:7]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:9]=1.[OH-].[Na+:48]>>[Na+:48].[F:13][C:10]([F:11])([F:12])[C:8]1[CH:7]=[C:6]([CH2:14][N:15]([C:39]2[N:40]=[N:41][N:42]([CH3:44])[N:43]=2)[C@@H:16]2[C:22]3[CH:23]=[C:24]([CH3:28])[CH:25]=[C:26]([CH3:27])[C:21]=3[N:20]([CH2:29][C@H:30]3[CH2:35][CH2:34][C@H:33]([C:36]([O-:38])=[O:37])[CH2:32][CH2:31]3)[CH2:19][CH2:18][CH2:17]2)[CH:5]=[C:4]([C:3]([F:2])([F:46])[F:45])[CH:9]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 178423621HCID 178423621, compound

Product 1

HCID 178423620HCID 178423620, compound

Procedure

Add to a 500 mL bottle Trans-4-[[(5S)-5-[[[3,5-bis(trifluoromethyl)phenyl]methyl](2-methyl-2H-tetrazol-5-yl)amino]-2,3,4,5-tetrahydro-7,9-dimethyl-1H-1-benzazepin-1-yl]methyl]-cyclohexanecarboxylic acid hydrate (20.16 g) ethanol SDA 3A (200.94 mL). Stir using a magnetic stir bar and slowly add 1 N sodium hydroxide (31.95 g). This is a clear solution.

Sources & evidence

ORD record
ord-7f3e5f8feec94c42bd750d15aedc4104
Source dataset
uspto-grants-2012_10
Patent number
US08299060B2

Reaction notes

Loading…