反应详情

Combine benzyl N-[(4R)-5,6-dihydro-4H-imidazo[1,2-a][1]benzazepin-4-yl]carbamate (120.0 g, 359.9 mmol) and ethanol (2.0 L) in a Büchi hydrogenator and add 10% palladium on carbon (Pd/C) (10.0 g, 9.4 mmol) slurried in toluene (200 ml). Hydrogenate (60 psi, ambient temperature) the mixture for approximately 64 hours. Filter the mixture through diatomaceous earth and wash the cake with THF (300 ml). Concentrate the filtrate under reduced pressure to give the title compound (60 g, 84%) as a white foam: MS (m/z): 200 (M+1).

1. filtrationFilter the mixture through diatomaceous earth
2. washwash the cake with THF (300 ml)
3. concentrationConcentrate the filtrate under reduced pressure