反应详情

Combine benzyl N-(1-methyl-5,6-dihydro-4H-imidazo[1,2-a][1]benzazepin-4-yl)carbamate (0.99 g, 2.85 mmol) and 10% Pd/C (200 mg, 1.88 mmol) in absolute ethanol (50 mL). Place the mixture on a Parr shaker for 7 hours (hydrogen (H2) 60 psi, ambient temperature). Remove the catalyst by filtration, add 10% Pd/C (200 mg, 1.88 mmol) to the filtrate, and place the mixture on a Parr shaker for 7 additional hours (60 psi, ambient temperature). After 7 hours, add more 10% Pd/C (189 mg, 1.78 mmol) and shake for 7 additional hours. Remove the catalyst by filtration and concentrate the filtrate under reduced pressure to give the title compound (0.53 g, 87%): MS (m/z): 214 (M+1).

1. customfor 7 hours
2. customRemove the catalyst
3. filtrationby filtration
4. customRemove the catalyst
5. filtrationby filtration
6. concentrationconcentrate the filtrate under reduced pressure