反应详情

温度

65 °C

To a solution of ethyl 1-(4-cyclopropoxybenzamido)cyclopropanecarboxylate (33.7 g, 6.48 mmol) in ethanol (380 mL), add sodium hydroxide (174.7 mL, 174.7 mmol) and stir the mixture at 65° C. for 3 hours. Cool the material to ambient temperature and concentrate under reduced pressure to remove the ethanol. Acidify the residue with 10% NaHSO4. Filter the resulting solid and wash with water (3×) and diethyl ether (2×). Dry the material in a vacuum oven to give the title compound (29.9 g, 98%) as a white solid: MS (m/z): 262 (M+1).

1. temperatureCool the material to ambient temperature
2. concentrationconcentrate under reduced pressure
3. customto remove the ethanol
4. filtrationFilter the resulting solid
5. washwash with water (3×) and diethyl ether (2×)
6. customDry the material in a vacuum oven