反应详情

Dissolve tert-butyl N-[1-[[(4R)-5,6-dihydro-4H-imidazo[1,2-a][1]benzazepin-4-yl]carbamoyl]cyclopropyl]carbamate (856 mg, 2.24 mmol) in dichloromethane (20 mL) and cool in an ice bath. Add trifluoroacetic acid (10 mL, 132.25 mmol). Remove the bath and stir the reaction for 1 hr. Concentrate the mixture under reduced pressure and add ethyl acetate. Wash with 1N NaOH and brine, dry over sodium sulfate, and concentrate the organic layer under reduced pressure to give the title compound (470 mg, 74%) as a white solid: MS (m/z): 283 (M+1).

1. temperaturecool in an ice bath
2. customRemove the bath
3. customthe reaction for 1 hr
4. concentrationConcentrate the mixture under reduced pressure
5. additionadd ethyl acetate
6. washWash with 1N NaOH and brine
7. dry with materialdry over sodium sulfate
8. concentrationconcentrate the organic layer under reduced pressure