1,4-Dioxane hydrochloride → HCID 53487250, compound

Participants

Reaction Steps

4-(3-Carboxymethyl-4-oxo-3,4-dihydro-quinazolin-6-yl)-[1,4]diazepane-1-carboxylic acid tert-butyl ester (9.8 g) was suspended in 20 mL of dioxane. To this suspension was added 4N HCl/dioxane solution (100 mL) and 20 mL of dioxane; the mixture was stirred at room temperature for 3 hours. At this time, the solvent was removed by concentration of the reaction mixture in vacuo, and to the residue was added tetrahydofuran. The mixture was again concentrated in vacuo. The residue was triturated with dry diethyl ether, filtered and washed with dry diethyl ether. In this manner, 14.74 g of a solid was obtained. This solid was used without further purification.

Provenance & Evidence