Ethyl chloroacetate → HCID 67211599, compound

Participants

Reaction Steps

ClCH2COOEt (1 equiv.) in dimethylforamide was added drop-wise to a solution of 4-(4-oxo-4,5-dihydro-3H-imidazo[4,5-c]pyridin-6-yl)piperazine-1-carboxylic acid tert-butyl ester, 3 and potassium carbonate (0.8 equiv.) in dimethylforamide. The solution was stirred overnight. The mixture was then diluted with water and extracted with methylene chloride. The combined organic layers were dried over magnesium sulfate, and the solvents were evaporated. The product was further purified over a silica column chromatography, eluting with ethyl acetate, to give 4 as a solid.

Provenance & Evidence