Ethyl chloroacetate → HCID 136079629, compound

Participants

Reaction Steps

A mixture of 4-(6-oxo-6,7-dihydro-1H-purin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester, 3 (1 g), potassium carbonate and dimethylforamide was stirred at room temperature for 2 h, then the solution of ClCH2COOEt (0.38 g/5 mL dimethylforamide) was added drop-wise into the reaction mixture, After stirring for 15 h, the solution was then partitioned between ethyl acetate and water. The ethyl acetate solution was washed with water, then it was dried over sodium sulfate and filtered, evaporated under reduced pressure, and purification of the residue by use of column chromatography to give 4.

Provenance & Evidence