2,6-Dichloropurine → 2-Chloroadenine

HRID 2068583Notes

Reaction equation

HRID 2068583 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4](Cl)[N:3]=1.[NH3:12].CO>>[NH2:12][C:4]1[N:3]=[C:2]([Cl:1])[N:10]=[C:9]2[C:5]=1[NH:6][CH:7]=[N:8]2

Participants

3

Reactant 2

HCID 53244122,6-DichloropurineHCID 21705897Ammonia methanol

Product 1

HCID 949042-ChloroadenineYield 60%

Conditions

Temperature
100 °C

Procedure

2,6-Dichloro-purine, 1 (30 g, 0.159 mol) was dissolved in a NH3/MeOH solution (300 ml, 30 wt % NH3 in MeOH). The reaction mixture was stirred in an autoclave and heated to 100° C. for 48 h. After cooling, the mixture was filtered and the solid was washed with methanol. Then it was dried in vacuum to afford 2 as a pale yellow powder (16 g, yield 60%).

Workup

  1. temperatureAfter cooling
  2. filtrationthe mixture was filtered
  3. washthe solid was washed with methanol
  4. customThen it was dried in vacuum

Sources & evidence

ORD record
ord-4f01496201724de1afe1645d591eba19
Source dataset
uspto-grants-2012_10
Patent number
US08299023B2

Reaction notes

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