Water → HCID 67211772, compound

Participants

Reaction Steps

To a stirred mixture of (6-amino-2-chloro-purin-7-yl)-acetic acid 1,1-dimethylethyl ester, 3 (5 g, 17.6 mmol) in dimethylsulfoxide (50 ml) was added tert-butyl piperazine-1-carboxylate (10 g, 53.8 mmol) at 120° C. After the addition, the mixture was stirred for about 14 h. Water (100 ml) and ethyl acetate (100 ml) were added to the reaction mixture. The organic layers was then washed with H2O several times, dried with Na2SO4 and concentrated to give crude product 4-(6-amino-7-tert-butoxycarbonylmethyl-7H-purin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester, 4 (7 g) which was not purified and used for the next reaction directly.

Provenance & Evidence