HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diphenyl Ether → 7-Bromoisoquinolin-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diphenyl Ether | HCID 7583 | — |
| Reactant | Tributylamine | HCID 7622 | — |
| Reactant | 4-Bromocinnamoyl azide | HCID 53903424 | — |
| Product | 7-Bromoisoquinolin-1-ol | HCID 11276133 | 30% |
Reaction Steps
A solution of compound 4 (121.6 g, 0.48 mol) and tributylamine (177.9 g, 0.96 mol) in diphenylether (1.2 L) was headed to 210° C. for 2 hours under N2. Then the mixture was cooled to room temperature, the precipitate was filtered, washed with hexane, and dried to give 5 (32 g, 30%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08299023B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-0bb9fed4f6fa4adc9412152eb85090d3 |
| Source note | uspto-grants-2012_10 |