HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[2-(2-Hydroxy-ethyl)-1-oxo-1,2-dihydro-isoquinolin-7-yl]piperazine-1-carboxylic acid tert-butyl ester → 2-(2-Hydroxy-ethyl)-7-piperazin-1yl-isoquinolin-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[2-(2-Hydroxy-ethyl)-1-oxo-1,2-dihydro-isoquinolin-7-yl]piperazine-1-carboxylic acid tert-butyl ester | HCID 59238165 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | 2-(2-Hydroxy-ethyl)-7-piperazin-1yl-isoquinolin-1-one | HCID 59238205 | 98% |
Reaction Steps
A solution of compound 7 (6 g, 16.1 mmol) in methylene chloride (20 mL) and trifluoroacetic acid (20 mL) was stirred at r.t for 1 h. Then the mixture was concentrated in vacuo to give the compound 8 (4.3 g, 98%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08299023B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-a416936ab77e4279a50097889ece7b0d |
| Source note | uspto-grants-2012_10 |