HuagongsheHuagongshe Chemistry Print Report · For research reference only
9-Fluorenylmethyl chloroformate → 4-[2-(2-hydroxy-ethyl)-1-oxo-1,2-dihydro-isoquinolin-7-yl]piperazine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 9-Fluorenylmethyl chloroformate | HCID 34367 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 2-(2-Hydroxy-ethyl)-7-piperazin-1yl-isoquinolin-1-one | HCID 59238205 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-[2-(2-hydroxy-ethyl)-1-oxo-1,2-dihydro-isoquinolin-7-yl]piperazine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester | HCID 59238193 | 59% |
Reaction Steps
To a solution of sat. aqueous NaHCO3 (80 mL), compound 8 (4.3 g, 15.7 mmol) in tetrahydrofuran was added chloroformic acid 9-fluorenylmethyl ester (1.5 eq.). The mixture was stirred for 2 h at room temperature, then concentrated. The residue was extracted with ethyl acetate, dried (sodium sulfate) and concentrated in vacuo to give 9 (4.6 g, yield 59%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08299023B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-e3669d51d9214a55aabb0f7a57a18aaf |
| Source note | uspto-grants-2012_10 |