Tributyltin Chloride → HCID 58303321, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 3-bromoimidazo[1,2-A]pyridine (0.10 g, 0.51 mmol) in THF (7.0 mL) under nitrogen atmosphere was cooled to −78° C. followed by dropwise addition of n-BuLi (1.30 M in hexane, 0.46 mL, 0.66 mmol). The resulting solution was stirred at same temperature for 45 min followed by addition of tributyltin chloride (0.14 mL, 0.53 mmol). The reaction mixture was then allowed to come to room temperature (45 min). After the completion of reaction (TLC monitoring), the reaction mixture was again cooled to −78° C. and quenched with dropwise addition of saturated NH4Cl solution. The reaction mixture was then extracted with EtOAc (2×25 ml). The combined organics was dried (Na2SO4), filtered and concentrated. The residue was used as such without further purification. MS: 409.10 (M+H)+.

Provenance & Evidence