Methanesulfonic Acid → HCID 59603090, compound

Participants

Reaction Steps

To a solution of 1-(5-(benzyloxy)benzo[d]thiazol-2-yl)-3-ethylurea I (1.20 g, 3.66 mmol) in DCM (100.0 mL) was added methanesulfonic acid (4.32 mL, 66.22 mmol) and the resulting reaction mixture was stirred at room temperature for 2 h. After the completion of reaction (TLC monitoring), the solvent was evaporated. The residue was cooled and then basified with saturated NaHCO3 solution followed by extraction with EtOAc (3×100 mL). The combined organics was washed with brine, dried (Na2SO4), filtered and concentrated to obtain the desired product (0.90 g) that was carried forward to the next step without further purification. MS: 238.10 (M+H)+.

Provenance & Evidence