Ethanol → HCID 11471099, compound

Participants

Reaction Steps

A solution of 7-chloro-1-methyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid (0.50 g, 2.10 mmol) and SOCl2 (2.0 mL) in EtOH (15.0 mL) was heated to 78° C. for 6 h. After the completion of reaction (TLC monitoring), EtOH was distilled off, added water and extracted with EtOAc (3×70 mL). The combined organics was washed with saturated NaHCO3 solution, dried (Na2SO4), filtered and concentrated to obtain the desired product in quantitative yields.

Provenance & Evidence