N-bromobutanimide → 7-Bromo-5-fluoroindolin-2-one

Participants

Reaction Steps

5-Fluoro-1,3-dihydro-indol-2-one 12a (1.5 g, 0.01 mmol) was dissolved in 15 mL of acetonitrile under stirring at room temperature, and N-bromosuccinimide (1.8 g, 0.01 mmol) was then added dropwise to the solution. Upon completion of the addition, the reaction mixture was stirred overnight and lots of precipitates were formed. The reaction was completed until TLC showed the disappearance of starting materials, and the reaction mixture was filtered to give 7-bromo-5-fluoro-1,3-dihydro-indol-2-one 12b (2 g, 87%) as a gray solid.

Provenance & Evidence