7-Bromo-5-fluoroindolin-2-one → HCID 25205215, compound

Participants

Reaction Steps

The title compound was prepared under the same conditions as described in step 6 of Example 1 with (R)-5-(2-hydroxy-3-morpholin-4-yl-propyl)-3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine-2-carbaldehyde 1f obtained from step 5 of Example 1 and 7-bromo-5-fluoro-1,3-dihydro-indol-2-one 12b as starting materials to give (R,Z)-2-(7-bromo-5-fluoro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-5-(2-hydroxy-3-morpholin-4-yl-propyl)-3-methyl-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one 14 (20 mg, yield 40%) as a yellow solid.

Provenance & Evidence