5-(4-Methoxy-phenyl)-1,3-dihydro-indol-2-one → (S,Z)-5-(2-hydroxy-3-morpholin-4-yl-propyl)-2-[5-(4-methoxy-phenyl)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-3-methyl-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one

HRID 2068746Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2068746
[OH:1][C@@H:2]([CH2:17][N:18]1[CH2:23][CH2:22][O:21][CH2:20][CH2:19]1)[CH2:3][N:4]1[CH2:9][CH2:8][C:7]2[NH:10][C:11]([CH:14]=O)=[C:12]([CH3:13])[C:6]=2[C:5]1=[O:16].[CH3:24][O:25][C:26]1[CH:31]=[CH:30][C:29]([C:32]2[CH:33]=[C:34]3[C:38](=[CH:39][CH:40]=2)[NH:37][C:36](=[O:41])[CH2:35]3)=[CH:28][CH:27]=1>>[OH:1][C@@H:2]([CH2:17][N:18]1[CH2:23][CH2:22][O:21][CH2:20][CH2:19]1)[CH2:3][N:4]1[CH2:9][CH2:8][C:7]2[NH:10][C:11](/[CH:14]=[C:35]3\[C:36](=[O:41])[NH:37][C:38]4[C:34]\3=[CH:33][C:32]([C:29]3[CH:30]=[CH:31][C:26]([O:25][CH3:24])=[CH:27][CH:28]=3)=[CH:40][CH:39]=4)=[C:12]([CH3:13])[C:6]=2[C:5]1=[O:16]

Komponenten

3

Edukt 2

HCID 201996345-(4-Methoxy-phenyl)-1,3-dihydro-indol-2-oneHCID 59375986(S)-5-(2-hydroxy-3-morpholin-4-yl-propyl)-3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine-2-carbaldehyde

Produkt 1

HCID 25205390(S,Z)-5-(2-hydroxy-3-morpholin-4-yl-propyl)-2-[5-(4-methoxy-phenyl)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-3-methyl-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-oneAusbeute 87,2 %

Versuchsvorschrift

The title compound was prepared under the same conditions as described in step 6 of Example 5 with (S)-5-(2-hydroxy-3-morpholin-4-yl-propyl)-3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine-2-carbaldehyde 5f obtained from step 5 of Example 5 and 5-(4-methoxy-phenyl)-1,3-dihydro-indol-2-one as starting materials to give (S,Z)-5-(2-hydroxy-3-morpholin-4-yl-propyl)-2-[5-(4-methoxy-phenyl)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-3-methyl-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one 21 (53 mg, yield 87.2%) as a yellow solid.

Aufarbeitung

  1. customThe title compound was prepared under the same conditions

Quellen und Nachweise

ORD-Eintrag
ord-a14e104bfa804615a8737cde3a7c8e35
Quelldatensatz
uspto-grants-2012_10
Patentnummer
US08299069B2

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