HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylpiperazine → 4-(3,5-Dichloropyridin-4-ylamino)-7-methoxy-8-(4-(4-methylpiperazin-1-yl)butoxy)-2H-chromen-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | 8-(4-bromobutoxy)-4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2H-chromen-2-one | HCID 24849567 | — |
| Product | 4-(3,5-Dichloropyridin-4-ylamino)-7-methoxy-8-(4-(4-methylpiperazin-1-yl)butoxy)-2H-chromen-2-one | HCID 24849888 | — |
Reaction Steps
The title compound was prepared from 1-methylpiperazine and 8-(4-bromobutoxy)-4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2H-chromen-2-one (Example 25) following the procedure outlined in Example 52. 1H NMR (400 MHz, DMSO-d6; bis HCl salt): δ 11.74 (br, 2H), 9.66 (s, 1H), 8.82 (s, 2H), 8.02 (d, 1H), 7.22 (d, 1H), 4.63 (s, 1H), 4.01 (t, 2H), 3.94 (s, 3H), 3.84-3.18 (br m, 10H), 2.81 (s, 3H), 1.97 (m, 2H), 1.75 (m, 2H); MS (ESI): 507.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745646B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-fb44e24b1aa94723b6b7febd270bf0a9 |
| Source note | uspto-grants-2010_06 |