HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → Ethyl 4-(2-isopropyl-1H-imidazol-1-yl)-3-nitrobenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 1H-Imidazole, 2-(1-methylethyl)- | HCID 123457 | — |
| Reactant | Ethyl 4-fluoro-3-nitrobenzoate | HCID 21277355 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Ethyl 4-(2-isopropyl-1H-imidazol-1-yl)-3-nitrobenzoate | HCID 59198553 | 81.7% |
Reaction Steps
A mixture of ethyl 4-fluoro-3-nitrobenzoate 4.26 g, 2-isopropylimidazole 2.20 g, N,N-diisopropylethylamine 5.2 mL and acetonitrile 40 mL was heated under reflux for 24 hours. After distilling the solvent off, water was added to the residue and extracted with ethyl acetate. The organic layer was washed with brine, dried over magnesium sulfate and removed of the solvent by distillation, to provide 4.95 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08299080B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-e0a71600cc8d42c2a17ac3942c1cbda0 |
| Source note | uspto-grants-2012_10 |