HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Ethyl 3-amino-4-(2-isopropyl-1H imidazol-1-yl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Ethyl 4-(2-isopropyl-1H-imidazol-1-yl)-3-nitrobenzoate | HCID 59198553 | — |
| Catalyst | HCID 178418390 | HCID 178418390 | — |
| Solvent | HCID 178418361 | HCID 178418361 | — |
| Product | Ethyl 3-amino-4-(2-isopropyl-1H imidazol-1-yl)benzoate | HCID 59198643 | — |
Reaction Steps
A mixture of ethyl 4-(2-isopropyl-1H-imidazol-1-yl)-3-nitrobenzoate as synthesized in above Production Example 9, 4.94 g, methanol 150 mL and 10% palladium carbon 500 mg was stirred for 16 hours in hydrogen atmosphere. After removing the insoluble matter by filtration, the solvent was distilled off to provide 4.12 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08299080B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-e6062c18a3c849cc9382ab27a4d9b45e |
| Source note | uspto-grants-2012_10 |