HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2068970Generated: October 26, 2026
Potassium Carbonate → Methyl 4-(2-cyclohexyl-1H-imidazol-1-yl)-2-methoxy-5-nitrobenzoate
https://huagongshe.com/reaction/2068970
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Dimethylacetamide | HCID 31374 | — |
| Reactant | Methyl 4-fluoro-2-methoxy-5-nitrobenzoate | HCID 10014029 | — |
| Reactant | 2-Cyclohexyl-1H-imidazole | HCID 11159405 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Methyl 4-(2-cyclohexyl-1H-imidazol-1-yl)-2-methoxy-5-nitrobenzoate | HCID 59198783 | 100.7% |
Reaction Steps
A mixture of methyl 4-fluoro-2-methoxy-5-nitrobenzoate 8.57 g, 2-cyclohexylimidazole 5.61 g, potassium carbonate 10.34 g and N,N-dimethylacetamide 75 mL was heated at 100° C. for 5 hours in nitrogen atmosphere. The reaction liquid was diluted with ethyl acetate, poured in water and the organic layer was separated. The organic layer was washed with brine, dried over magnesium sulfate and removed of the solvent by distillation to provide 13.52 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08299080B2 |
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| Source dataset | uspto-grants-2012_10 |
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| ORD ID | ord-1820dcb31c934e978a4c618e9481ba20 |
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| Source note | uspto-grants-2012_10 |
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