Sulfuric Acid → 1-(4-Fluoro-2-methoxy-5-nitrophenyl)ethanone

HRID 2068979Notes

Reaction equation

HRID 2068979 reaction equation
S(=O)(=O)(O)O.[F:6][C:7]1[CH:12]=[CH:11][C:10]([C:13](=[O:15])[CH3:14])=[C:9]([O:16][CH3:17])[CH:8]=1.[N+:18]([O-])([O-:20])=[O:19].[K+]>>[F:6][C:7]1[C:12]([N+:18]([O-:20])=[O:19])=[CH:11][C:10]([C:13](=[O:15])[CH3:14])=[C:9]([O:16][CH3:17])[CH:8]=1

Participants

4

Reactant 3

HCID 1118Sulfuric AcidHCID 24434Potassium NitrateHCID 1428871-(4-Fluoro-2-methoxyphenyl)ethan-1-one

Product 1

HCID 591989251-(4-Fluoro-2-methoxy-5-nitrophenyl)ethanoneYield 92.8%

Procedure

In nitrogen atmosphere, conc. sulfuric acid 36 mL was added to 1-(4-fluoro-2-methoxyphenyl)ethanone 5.50 g, followed by heating to homogeneity. Cooling the same with salt-ice, potassium nitrate 3.47 g was added little by little, followed by an hour's stirring. The reaction liquid was poured in ice water, and the precipitated crystals were recovered by filtration and washed with water. Drying the crystals, 6.47 g of the title compound was obtained.

Workup

  1. temperatureby heating to homogeneity
  2. additionwas added little by little,
  3. waitfollowed by an hour
  4. customThe reaction liquid
  5. filtrationthe precipitated crystals were recovered by filtration
  6. washwashed with water
  7. customDrying the crystals

Sources & evidence

ORD record
ord-46c194b03f714370a8d3b7d5601270c3
Source dataset
uspto-grants-2012_10
Patent number
US08299080B2

Reaction notes

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