HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → Ethyl 5-[(E)-2-ethoxycarbonylvinyl]-3-methyl-1H-pyrrole-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | ethyl 5-formyl-3-methyl-1H-pyrrole-2-carboxylate | HCID 1113514 | — |
| Reactant | Propanedioic acid, monoethyl ester | HCID 3595298 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | Ethyl 5-[(E)-2-ethoxycarbonylvinyl]-3-methyl-1H-pyrrole-2-carboxylate | HCID 59198650 | 47.7% |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
Ethyl 5-formyl-3-methyl-1H-pyrrole-2-carboxylate 470 mg, monoethyl malonate 378 mg, piperidine 0.05 mL and pyridine 6 mL were mixed and stirred at 100° C. for 38 hours. Ice water was added to the reaction liquid and the precipitate was recovered by filtration. The precipitate was washed with water and dried in flowing air under heating to provide 311 mg of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08299080B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-03e6a0fb06e24cdfbdfa2e6c1dfb14ae |
| Source note | uspto-grants-2012_10 |