HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2068996Generated: October 26, 2026
Benzyl Bromide → 1-Benzyl-3-methoxycarbonylamino-4-methyl-pyridinium bromide
https://huagongshe.com/reaction/2068996
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Methyl N-(4-methylpyridin-3-yl)carbamate | HCID 11672725 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 1-Benzyl-3-methoxycarbonylamino-4-methyl-pyridinium bromide | HCID 66770203 | 101.8% |
Reaction Steps
1-(Bromomethyl)benzene (19 g, 111 mmol, 1.10 equiv.) was added to a solution of methyl 4-methylpyridin-3-ylcarbamate (17 g, 102 mmol, 1.00 equiv.) in toluene (500 mL). The solution was stirred at about 110° C. for about 16 hours. After cooling to ambient temperature, the solids were collected by filtration and washed with toluene to afford the title product as a light brown solid (35 g; yield=97%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08299084B2 |
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| Source dataset | uspto-grants-2012_10 |
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| ORD ID | ord-ed2443c1174f4ec99825d61dc5ecf2ca |
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| Source note | uspto-grants-2012_10 |
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