4-(1-(4-Nitronaphthalen-1-yloxy)ethyl)pyridin-2-amine → 4-(1-(4-Aminonaphthalen-1-yloxy)ethyl)pyridin-2-amine

Participants

Reaction Steps

A solution of 4-(1-(4-Nitronaphthalen-1-yloxy)ethyl)pyridin-2-amine (38) (91 mg, 0.294 mmol) in MeOH (15 mL) and AcOH (3.0 mL) was passed through a Thales H-cube (1.0 mL·min−1, 30° C., 55 mm, 10% Pt/C Cat-Cart, full hydrogen mode). The volatiles were removed under reduced pressure, leaving a purple solid, which was then subjected to SCX capture and release to give the title compound (39) (81 mg, 99%) as a purple oil: m/z 280 (M+H)+ (ES+).

Provenance & Evidence